Orthobond

Overview

Orthobond has pioneered a groundbreaking method to permanently alter the surfaces of metal and polymer medical devices to destroy bacteria that contact these surfaces during implant surgery, distinguishing itself from conventional approaches that often face resistance issues. Unlike drug classified solutions that may contribute to bacterial resistance, Orthobond’s technology ensures broad-spectrum antimicrobial activity without these challenges because it does not utilize an antibiotic drug. This innovation is crucial given the heightened risk of infections from bacteria colonizing implant devices, which are significantly more resistant than free-floating bacteria. Orthobond’s solution, Ostaguard, features a polycationic surface that attracts and destroys bacteria by binding to their negatively charged peptidoglycan layer, causing membrane destabilization and intracellular leakage. This nanoscale attack prevents biofilm formation, a common issue with implants.