The life sciences and therapeutic landscapes are incredibly dynamic and rapidly changing. What was relevant 5 years ago is more than likely outdated and mute today. The real challenge is staying ahead of the curve to foresee what will be relevant 5 years from now with these continuously growing markets. Kineticos Life Sciences white papers provide a unique and different primer on various therapeutic areas, indications, and technologies. We not only offer our position on the associated epidemiology and history, market trends, addressable patient populations, technologies, assets, IP, and relevant competitors, we will take the next step and provide an important view of the future discussing the challenges and possibilities for each of these markets.


Visualizing the Future of Contract Development and Manufacturing for Cell and Gene Therapies

“Next-generation medicines, such as cell and gene therapy, are providing significant opportunities for growth in the innovator, CRO, and CDMO marketplaces. However, there are numerous challenges associated with these therapies that create measurable risk.”

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A Primer on CAR-T Cell Therapy

“In the world of cancer detection, diagnosis, and treatment, there is a continuous stream of new ideas and inventions that alter our understanding of standards of care and patient outcomes… Although there are many treatment options available, few have received the same level of public attention as chimeric antigen receptor T cell (CAR-T) therapy. CAR-T therapy involves the reprogramming of the hosts’ (or patient’s) own T cells.”

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A Primer on Immuno-Oncology: Part 2 – Targeted Redirection of T Cells

In the second part of this Immuno-Oncology Primer, we will provide an overview of immune checkpoint inhibitors, bispecific T cell engagers, and CAR T cells.

“Immune checkpoint inhibitors, BiTEs, and CAR-T cells all utilize T cells in their fight against cancer, but in differing ways.  Whereas immune checkpoint inhibitors amplify antigen-specific T cell response, BiTEs provide assistance in increasing T cell activity, and CAR-T cell therapy augments the capabilities of T cells.”

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A Primer on Immuno-Oncology: Part 1

In the first part of the Immuno-Oncology Primer, we will provide an overview of anti-cancer vaccines and cytokines before delving into a discussion of immune checkpoint inhibitors.

“These successes have refocused attention back on to immunotherapeutic approaches for treating cancer; specifically, the discovery and clinical successes of immune checkpoint inhibitors have revolutionized cancer immunotherapy, and the cancer immunotherapy market is forecasted to have sales of >$93B in 2023, the majority of which may be attributed to immune checkpoint inhibitors…”

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Primary Research: An Effective Risk Mitigation Tool

The life science industry relies heavily on market research. The evolving nature of the industry, along with the extremely high financial stakes, stresses the need for market data. Whether it is an emerging biotech trying to determine their molecule’s lead indication, or a diagnostic company exploring a new geographic market, there is no substitute for having a comprehensive understanding of market dynamics supported by an in-depth, data-supported analysis.

“One of the most important reasons for companies to consider outsourcing primary research is for the same reason these companies want to conduct primary research in the first place; it is a unique problem associated with performing primary research.”

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A Primer on Gene Editing

Gene editing has recently emerged as a revolutionary scientific tool which may be utilized for therapeutic applications such as curing disease, as well as for the creation of animal models for disease research and therapeutics development, agricultural development, genome wide screening, and basic research. In the past two decades, great advances have been made in genome editing technologies through the use of systems, comprised of nucleases combined with target sequence specific DNA binding domains, allowing for direct manipulation of virtually any gene.

“This technology holds great implications for the medical community, as gene editing (through nucleases) may be harnessed to discover cures for diseases, target genes that might be harmful to the organism, and ultimately ameliorate the potential for genetic disorders”

Click here to read the full Primer.


A Primer on Regenerative Medicine

The two most groundbreaking and fastest-growing areas of regenerative medicine are cell and gene therapies, with small molecules and biologics, tissue-engineered biomaterials and scaffolds, and implantable devices representing the majority of other sub-areas. Cell therapies utilize fully-differentiated cells and/or progenitor cells to repair diseased tissue and overall body systems, either through an autologous or allogenic pathway. Moreover, the immune properties of these cells can be used as an immunological treatment against pathogens and cancer.

“The relevance of these therapies is illustrated by the fact that, according to a study conducted by BIS Research in 2018, cell therapies have had the fastest compound annual growth rate out of any other regenerative treatment methods.”

Click here to read the full Primer.

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